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Associated genetic variations can serve as powerful pointers to regions of the human genome where disorder-causing problems reside, according to the National Human Genome Research Institute.'We identified one genome-wide significant locus for anorexia nervosa on chromosome 12, in a region previously shown to be associated with type 1 diabetes and autoimmune disorders,' said lead investigator Dr Cynthia Bulik, founding director of the UNC Center of Excellence for Eating Disorders.'We also calculated genetic correlations - the extent to which various traits and disorders are caused by the same genes,' said Dr Bulik.'Anorexia nervosa was significantly genetically correlated with neuroticism and schizophrenia, supporting the idea that anorexia is indeed a psychiatric illness.''But, unexpectedly, we also found strong genetic correlations with various metabolic features including body composition (BMI) and insulin-glucose metabolism.
This finding encourages us to look more deeply at how metabolic factors increase the risk for anorexia nervosa,' Dr Bulik said.
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